Effects of protein intake variation and omega-3 polyunsaturated fatty acids on renal function in chronic renal...

Fifteen patients with chronic renal disease of various origin were investigated after 4 weeks protein restriction, after 4 weeks high protein intake and finally, after 8 weeks dietary supplementation with omega-3 polyunsaturated fatty acids (PUFA's), while adhering to a high protein intake. The highest values for effective renal plasma flow and glomerular filtration rate were observed after 8 weeks dietary supplementation with omega-3 PUFA's without a relationship with baseline values. Calculated renal resistance fell after omega-3 PUFA supplementation. Whether long term dietary supplementation with omega-3 PUFA's will influence the progression of chronic renal insufficiency in man needs further study.