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Exploring human CYP4 enzymes: Physiological roles, function in diseases and focus on inhibitors
Manzhen Zhou1, Junda Li1, Jinyi Xu1
1Department of Medicinal Chemistry, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Drug Discovery Today
|March 23, 2023
Summary
Cytochrome P450 (CYP)4 enzymes regulate eicosanoid pathways and are targets for diseases like cancer. This review details CYP4 inhibitors, aiding future drug discovery for conditions involving CYP4.
Area of Science:
- Biochemistry
- Pharmacology
- Molecular Biology
Background:
- Cytochrome P450 (CYP)4 enzymes are key monooxygenases involved in fatty acid and eicosanoid metabolism.
- These enzymes regulate critical eicosanoid signaling pathways.
- Dysregulation of CYP4 is implicated in diseases such as cancer, cardiovascular conditions, and inflammation.
Purpose of the Study:
- To review recent advancements in the field of CYP4 enzymes.
- To discuss the physiological and pathological roles of the CYP4 family.
- To categorize known CYP4 inhibitors by chemical class to guide future drug development.
Main Methods:
- Literature review of CYP4 enzyme research.
- Analysis of physiological and pathological functions of CYP4.
- Compilation and classification of small-molecule CYP4 inhibitors based on chemical structure.
Main Results:
- CYP4 enzymes are crucial for endogenous fatty acid and eicosanoid metabolism.
- CYP4 represents a promising therapeutic target for various human diseases.
- A systematic classification of CYP4 inhibitors has been compiled.
Conclusions:
- Small-molecule inhibitors targeting CYP4 offer potential therapeutic strategies for cancer, cardiovascular diseases, and inflammation.
- Understanding CYP4 physiology and pathology is vital for drug development.
- The compiled inhibitor classes provide a foundation for designing novel drug candidates.
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