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Radiology-Pathology and Surgical Correlation in Astroblastoma
F Sprenger1, E B da Silva2, M S Cavalcanti3
1From the Department of Radiology (F.S., B.C.d.A.T.), Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil flaviasprenger@gmail.com.
AJNR. American Journal of Neuroradiology
|March 23, 2023
Summary
Astroblastoma, a rare glial tumor primarily in young females, is now diagnosed using MN1 gene alterations. This case highlights typical imaging and histology of an MN1-altered astroblastoma.
Area of Science:
- Neuro-oncology
- Pathology
- Molecular Diagnostics
Background:
- Astroblastoma is a rare astrocytic glial neoplasm.
- It predominantly affects young females aged 10-30 years.
- Manifestations range from low- to high-grade.
Purpose of the Study:
- To describe a case of astroblastoma with characteristic imaging and histological features.
- To emphasize the diagnostic role of MN1 alterations in astroblastoma.
Main Methods:
- Review of imaging characteristics.
- Histopathological analysis.
- Molecular analysis for MN1 alterations.
Main Results:
- The case presented typical imaging findings of astroblastoma.
- Histological examination revealed characteristic features.
- Molecular analysis confirmed MN1 alterations, supporting the diagnosis.
Conclusions:
- MN1 alterations are fundamental for diagnosing astroblastoma.
- This case exemplifies typical features of MN1-altered astroblastoma.
- Integration of imaging, histology, and molecular data is crucial for accurate diagnosis.
