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Assessment of subclinical left ventricular systolic dysfunction in patients with type 2 diabetes: Relationship with

Yanyan Chen1, Ying Zhang1, Yi Wang1

  • 1Department of Endocrinology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.

Journal of Diabetes
|March 23, 2023
PubMed

Insights

High glycated hemoglobin (HbA1c) and triglyceride levels are linked to subclinical left ventricular (LV) systolic dysfunction in type 2 diabetes patients. HbA1c shows prognostic significance for myocardial damage progression.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with cardiovascular complications.
  • Microvascular complications and subclinical left ventricular (LV) dysfunction are common in T2DM.
  • Glycated hemoglobin (HbA1c) is a key marker for diabetes management.

Purpose of the Study:

  • To investigate the association between HbA1c, microvascular complications, and subclinical LV systolic dysfunction in T2DM patients.
  • To determine the correlation strength in asymptomatic T2DM individuals.
  • To identify independent risk factors for reduced LV function.

Main Methods:

  • 152 T2DM patients with preserved LV ejection fraction were enrolled.
  • Global longitudinal strain (GLS) was used to assess subclinical LV function (cutoff <18%).
  • Univariate and multiple logistic regression analyses were performed, adjusting for clinical covariables.

Main Results:

  • Reduced GLS was associated with higher HbA1c, triglycerides, systolic blood pressure, fasting glucose, heart rate, diabetic retinopathy, and urinary albumin creatinine ratio (UACR).
  • Independent risk factors for reduced GLS included HbA1c (OR 1.66), UACR (OR 2.48), and triglycerides (OR 1.84).
  • HbA1c demonstrated predictive value for subclinical LV systolic dysfunction (AUC: 0.74).

Conclusions:

  • Subclinical LV systolic dysfunction in asymptomatic T2DM patients is linked to HbA1c, diabetic complications, and triglyceride levels.
  • HbA1c holds prognostic significance for the progression of myocardial damage.
  • Early detection and management of these factors are crucial for preventing cardiac complications in T2DM.
Abstract

Keywords:
2型糖尿病global longitudinal strainglycated hemoglobinmicrovascular complicationstype 2 diabetes mellitusventricular function全局纵向应变微血管并发症心室功能糖化血红蛋白

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