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Sauchinone inhibits breast cancer cell proliferation through regulating microRNA-148a-3p/HER-2 axis

Xiaolei Hu1, Jie Wang2, Pei Shang1

  • 1Department of Breast Surgery, Nanfang Hospital, Southern Medical University, Guangzhou City, China.

Thoracic Cancer
|March 23, 2023
PubMed
Abstract

Insights

Sauchinone, derived from Saururus chinensis, effectively inhibits breast cancer progression by downregulating human epidermal growth factor receptor (HER)-2. This natural compound shows promise as an anticancer agent for breast cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Sauchinone, extracted from Saururus chinensis root, possesses known antitumor properties.
  • The specific role of sauchinone in breast cancer remains underexplored.

Purpose of the Study:

  • To investigate the effects of sauchinone on breast cancer cells in vitro and in vivo.
  • To elucidate the molecular mechanisms underlying sauchinone's action in breast cancer.

Main Methods:

  • In vitro assays evaluated cell apoptosis, proliferation, and cell cycle distribution.
  • Western blot analysis detected relevant protein expression.
  • A xenograft mouse model was used to assess in vivo efficacy.

Main Results:

  • Sauchinone reduced proliferation and survival while inducing apoptosis in breast cancer cell lines (MCF-7, Bcap-37).
  • Sauchinone upregulated miR-148a-3p, which targets human epidermal growth factor receptor (HER)-2.
  • Sauchinone downregulated HER-2 expression, inhibiting breast cancer progression in vitro and in vivo.

Conclusions:

  • Sauchinone inhibits breast cancer progression by regulating the miR-148a-3p/HER-2 axis.
  • Sauchinone demonstrates potential as an effective anticancer agent for breast cancer.
Keywords:
apoptosisbreast cancermiR-148a-3pproliferationsauchinone

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