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Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
Published on: August 13, 2021
Nanotechnologically Relevant Aspects of COVID-19 Vaccines
Ryan J Batley1, Shaneel Chandra1,2
1College of Science and Sustainability, School of Health, Medical and Applied Sciences, Central Queensland University, 4702 Rockhampton North, Queensland, Australia.
Abstract:
The COVID-19 pandemic has affected several facets of human existence globally. To counter the spread of the virus, several vaccines have been developed and administered worldwide, using various technologies. Due to the need for the mRNA to be safely 'protected' until it can reach the host's cells, innovative transport, casing, stabilization and attachment mechanisms need to be harnessed to accompany the mRNA. Nanotechnology has featured in several such capacities. Therefore, our short review explores the role of nanomaterials in COVID vaccines, with a core focus on those based on mRNA. Often, the chemistry of these nanomaterials is critical to their success in these, and such important aspects are highlighted in our review. Towards the end, we have also discussed the various vaccine types.
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