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Updated: Aug 5, 2025

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
Mechanism and treatments of antipsychotic-induced weight gain
Wujie Ye1, Jingyu Xing1, Zekai Yu1
1School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Abstract:
The long-term use of antipsychotics (APs) may cause a variety of diseases, such as metabolic syndrome, antipsychotic-induced weight gain (AIWG), and even obesity. This paper reviews the various mechanisms of AIWG and obesity in detail, involving genetics, the central nervous system, the neuroendocrine system, and the gut microbiome. The common drug and non-drug therapies used in clinical practice are also introduced, providing the basis for research on the molecular mechanisms and the future selection of treatments.
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