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Regulated cell death pathways in kidney disease.

Ana B Sanz^1,2, Maria Dolores Sanchez-Niño^1,2,3, Adrian M Ramos^1,2

¹Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.

Nature Reviews. Nephrology

|March 24, 2023

Summary

This summary is machine-generated.

Imbalances in cell death and proliferation contribute to kidney disease. Understanding regulated cell death pathways, like apoptosis and necrosis, offers potential therapeutic targets for kidney disorders.

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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

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Published on: December 27, 2016

Area of Science:

Nephrology
Cell Biology
Pathology

Background:

Kidney diseases often stem from disruptions in cell number, involving either excessive cell death or uncontrolled proliferation.
Conditions like acute kidney injury, chronic kidney disease, cystic disease, and kidney cancer are linked to abnormal cell dynamics.

Purpose of the Study:

To explore the role of regulated cell death (RCD) pathways in the pathogenesis of kidney diseases.
To identify potential therapeutic strategies targeting RCD in kidney disorders.

Main Methods:

Review of existing literature on cell death modalities and kidney disease.
Analysis of the involvement of apoptosis, necrosis, ferroptosis, necroptosis, and pyroptosis in renal pathology.

Main Results:

Dysregulated cell death and proliferation are central to kidney disease development.
Specific RCD pathways, including ferroptosis, necroptosis, and pyroptosis, can directly cause kidney injury or promote inflammation.
Interconnections exist between various RCD pathways, sharing triggers and protective mechanisms.

Conclusions:

Regulated cell death pathways are critical players in kidney disease pathogenesis.
Targeting RCD offers a promising avenue for therapeutic intervention in kidney diseases.