Perceived Sleep Quality in Individuals with Inborn Errors of Immunity

Area of Science:

• Immunology
• Sleep Medicine
• Patient Health Outcomes

Background:

• Chronic sleep disturbances negatively impact quality of life and increase mortality risk.
• Patients with chronic health conditions frequently report poor sleep quality.
• Elevated fatigue levels are common in individuals diagnosed with inborn errors of immunity (IEI).

Purpose of the Study:

• To investigate and understand the perceived sleep quality in individuals diagnosed with inborn errors of immunity (IEI).

Main Methods:

• A survey incorporating the validated Sleep Quality Scale was distributed via social media platforms.
• The survey targeted individuals diagnosed with inborn errors of immunity (IEI).

Main Results:

• 71.8% of participants reported moderate sleep quality impairment, with a mean Sleep Quality Scale score of 43.0.
• IEI patients exhibited poorer sleep quality compared to other patient populations and healthy controls.
• Sleep quality was associated with age, sleep duration, nocturnal awakenings, daytime napping, chronic pain, and mental health diagnoses.

Conclusions:

• Individuals with inborn errors of immunity (IEI) perceive a moderate level of sleep quality impairment.
• Routine screening for sleep quality is recommended for all patients diagnosed with IEI.
• Prompt referral for further evaluation and intervention is advised for IEI patients identified with impaired sleep quality.