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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Protein Networks02:26

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Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Related Experiment Video

Updated: Aug 5, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Potential biomarkers of aortic dissection based on expression network analysis.

Junbo Feng1, Yuntao Hu1, Peng Peng1

  • 1Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230000, People's Republic of China.

BMC Cardiovascular Disorders
|March 24, 2023
PubMed
Summary
This summary is machine-generated.

Altered microRNA-associated circRNA-mRNA networks are implicated in aortic dissection (AD). These findings suggest microRNAs could be potential biomarkers for diagnosing and treating this severe condition.

Keywords:
Aortic dissectionGO analysisPPI networkmRNAmiRNA

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Area of Science:

  • Genomics
  • Molecular Biology
  • Biomedical Research

Background:

  • Aortic dissection (AD) is a rare but life-threatening condition with high mortality.
  • The precise pathogenesis of AD remains incompletely understood, necessitating further investigation for clinical significance.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying aortic dissection.
  • To identify potential diagnostic and therapeutic biomarkers for AD.

Main Methods:

  • Downloaded and analyzed 28 Gene Expression Omnibus samples (14 AD, 14 healthy controls).
  • Utilized bioinformatics tools (Limma, StarBasev2.0, Cytoscape, STRING) for gene expression analysis, miRNA-circRNA-mRNA network prediction, and functional enrichment.
  • Performed functional enrichment analysis on 200 differentially expressed genes.

Main Results:

  • Identified 200 differentially expressed genes associated with AD.
  • Predicted 2720 miRNA-mRNA pairs, highlighting hsa-miR-650, hsa-miR-625-5p, hsa-miR-491-5p, and hsa-miR-760.
  • Predicted 7106 circRNA-miRNA pairs and identified key genes (e.g., CDH2, AKT1, WNT5A) interacting with the top miRNAs.

Conclusions:

  • Demonstrated altered miRNA-associated circRNA-mRNA networks in AD.
  • Suggested that microRNAs play a critical role in AD pathogenesis.
  • Proposed that these molecular networks represent potential biomarkers for AD diagnosis and treatment.