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Antipsychotic drugs and their effects on cognitive function: protocol for a systematic review, pairwise, and network
Lena Feber1, Natalie Peter2, Johannes Schneider-Thoma2
1Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany. lena.feber@tum.de.
Systematic Reviews
|March 24, 2023
Summary
This network meta-analysis ranks antipsychotics for schizophrenia
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Antipsychotic drug efficacy varies for cognitive symptoms in schizophrenia.
- A comprehensive review is lacking to guide treatment choices.
- Network meta-analysis is needed due to the large number of available antipsychotics.
Purpose of the Study:
- To conduct a network meta-analysis (NMA) of randomized controlled trials (RCTs).
- To rank antipsychotic medications based on their effectiveness in improving cognitive functioning in schizophrenia patients.
- To provide evidence-based guidance for clinicians and patients.
Main Methods:
- Included RCTs comparing antipsychotics or placebo in schizophrenia patients.
- Primary outcome: composite cognitive functioning score (preferentially MATRICS).
- Secondary outcomes: cognitive domains, functioning, quality of life; assessed risk of bias and confidence in results.
Main Results:
- The study will rank antipsychotics by their effect on cognitive functioning.
- Results will integrate direct and indirect evidence from RCTs.
- Network meta-analysis will provide a comprehensive comparison of antipsychotic efficacy.
Conclusions:
- This NMA will inform evidence-based treatment selection for cognitive deficits in schizophrenia.
- Findings will support shared decision-making between patients and physicians.
- The study addresses a critical gap in understanding antipsychotic effects on cognition.
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