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Related Experiment Video

Updated: Aug 5, 2025

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
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Natural products regulate mitochondrial function in cognitive dysfunction-A scoping review.

Jinmei Tuo1,2,3, Yan Peng1, Yushuang Linghu2

  • 1Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Frontiers in Pharmacology
|March 24, 2023
PubMed
Summary
This summary is machine-generated.

Natural products show promise in treating neurodegenerative diseases and cognitive dysfunction by improving mitochondrial function. These findings highlight natural compounds as potential therapeutic targets for brain health.

Keywords:
cognitive dysfunctionmitochondrial functionnatural productsneurodegenerative diseasesscoping review

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Mitochondrial Biology

Background:

  • Neurodegenerative diseases and cognitive dysfunction pose significant health challenges.
  • Current treatments may cause cognitive side effects.
  • Mitochondria play a crucial role in cognitive function.

Purpose of the Study:

  • To review the scientific literature on how natural products regulate mitochondrial function in relation to cognitive processes.
  • To identify natural products that may ameliorate cognitive dysfunction.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, and Google Scholar.
  • Inclusion of English articles published between October 15, 2017, and October 15, 2022.
  • Analysis and synthesis of data from fourteen selected studies.

Main Results:

  • Natural products demonstrate the ability to improve cognitive function.
  • These compounds can mitigate cognitive deficits by addressing mitochondrial dysfunction.
  • Evidence suggests a direct link between natural product intervention and improved mitochondrial health.

Conclusions:

  • Natural products represent a promising therapeutic avenue for neurodegenerative diseases and associated cognitive impairments.
  • Targeting mitochondrial dysfunction with natural compounds may offer a novel strategy for enhancing cognitive health.
  • Further research into specific natural products and their mechanisms is warranted.