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Updated: Aug 5, 2025

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 3. Aerobiology
Published on: October 3, 2016
Use of expert consensus to develop a shared list of procedures with potential for aerosol generation during the
Dana E Pepe1,2,3, Preeti Mehrotra1,2,3, Lou Ann Bruno-Murtha4,3
1Division of Infection Control/Hospital Epidemiology, Silverman Institute for Health Care Quality and Safety, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Insights
The COVID-19 pandemic revealed confusion over aerosol-generating procedures. Expert consensus was developed by Massachusetts healthcare epidemiologists to address this critical knowledge gap for healthcare personnel safety.
Area of Science:
- Infectious Diseases
- Epidemiology
- Public Health
Background:
- The COVID-19 pandemic underscored a lack of consensus on defining aerosol-generating procedures (AGPs).
- This ambiguity created uncertainty regarding potential risks to healthcare personnel.
- Existing guidance was insufficient during the early stages of the pandemic.
Purpose of the Study:
- To establish expert consensus on the definition of aerosol-generating procedures.
- To address a critical gap in healthcare guidance during the COVID-19 pandemic.
- To mitigate risks faced by healthcare personnel.
Main Methods:
- Convening a group of Massachusetts healthcare epidemiologists.
- Utilizing expert opinion to develop consensus.
- Focusing on areas lacking broader established guidance.
Main Results:
- Development of a consensus definition for aerosol-generating procedures.
- Identification of key procedures with high aerosol generation potential.
- Clarification of risks associated with specific medical interventions.
Conclusions:
- Expert consensus provides a framework for defining aerosol-generating procedures.
- Standardized definitions are crucial for healthcare worker safety during pandemics.
- This consensus aids in risk assessment and infection control strategies.
Abstract:
The coronavirus disease 2019 (COVID-19) pandemic highlighted the lack of agreement regarding the definition of aerosol-generating procedures and potential risk to healthcare personnel. We convened a group of Massachusetts healthcare epidemiologists to develop consensus through expert opinion in an area where broader guidance was lacking at the time.
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