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Updated: Aug 5, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy
Haiqi Jia1, Tingyu Shi1, Tian He1
1Key Laboratory of Organosilicon Chemistry and Materials Technology of Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China. liyang@hznu.edu.cn.
Abstract:
Photodynamic therapy (PDT) has attracted a great deal of attention in the field of cancer treatment due to its non-invasive nature, high repeatability and minimal side effects. Due to the dual effect of organic small molecule donors and platinum receptors, supramolecular coordination complexes (SCCs) exhibit stronger reactive oxygen species (ROS) production capacity and have become a promising class of photosensitizers (PSs). Herein, we report a rhomboid SCC MD-CN based on the D-A structure with aggregation-induced emission (AIE). The results show that the as-prepared nanoparticles (NPs) had excellent photosensitization efficiency and good biocompatibility. Most importantly, they exhibited potential killing effects on cancer cells in vitro under light irradiation.
