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Updated: Aug 5, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
An efficient data integration scheme for synthesizing information from multiple secondary datasets for the parameter
Chixiang Chen1,2, Ming Wang3, Shuo Chen1
1Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract:
Many observational studies and clinical trials collect various secondary outcomes that may be highly correlated with the primary endpoint. These secondary outcomes are often analyzed in secondary analyses separately from the main data analysis. However, these secondary outcomes can be used to improve the estimation precision in the main analysis. We propose a method called multiple information borrowing (MinBo) that borrows information from secondary data (containing secondary outcomes and covariates) to improve the efficiency of the main analysis. The proposed method is robust against model misspecification of the secondary data. Both theoretical and case studies demonstrate that MinBo outperforms existing methods in terms of efficiency gain. We apply MinBo to data from the Atherosclerosis Risk in Communities study to assess risk factors for hypertension.
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