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Related Experiment Videos

Pyrethroid effects on schedule-controlled behavior: time and dosage relationships.

D B Peele1, K M Crofton

  • 1Northrop Services, Inc., Environmental Sciences, Research Triangle Park, NC 27709.

Neurotoxicology and Teratology
|September 1, 1987
PubMed
Summary
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Type I (permethrin) and Type II (cypermethrin) pyrethroid insecticides differentially affect operant behavior in rats. These insecticides show distinct potency, time-course, and behavioral disruption patterns, even at sub-lethal doses.

Area of Science:

  • Neurotoxicology
  • Behavioral Pharmacology
  • Environmental Science

Background:

  • Pyrethroid insecticides are classified into Type I and Type II based on toxicity profiles.
  • Previous research focused on lethal dosages, leaving effects on complex behaviors less understood.

Purpose of the Study:

  • To investigate the effects of permethrin (Type I) and cypermethrin (Type II) on acquired (operant) behavior in rats.
  • To determine acute dosage-effect and time-course relationships for these pyrethroids on schedule-controlled behavior.

Main Methods:

  • Long-Evans rats were trained on a multiple variable-interval schedule for food reinforcement.
  • Permethrin and cypermethrin were administered orally at various dosages and pre-session times.
  • Effects on response rates and between-component response patterning were analyzed.

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Main Results:

  • Permethrin decreased responding irrespective of baseline rate, while cypermethrin's effects were dependent on baseline responding, with lower rates being more sensitive.
  • Cypermethrin exhibited faster onset and recovery from rate-decreasing effects (recovery by 12 hr) compared to permethrin (recovery by 48 hr).
  • Response patterning disruption was more rapid and transient with cypermethrin than with permethrin.

Conclusions:

  • Permethrin and cypermethrin exhibit type-specific effects on operant behavior in rats.
  • These pyrethroids demonstrate differential potency and time-course of action on schedule-controlled behavior at sub-lethal dosages.