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The crosstalk between ubiquitination and endocrine therapy
Yidong Ge1,2, Ziqing Zhan1,2, Meng Ye3,4
1The Department of Medical Oncology, The First Hospital of Ningbo University, Ningbo University, Ningbo, 315010, China.
Journal of Molecular Medicine (Berlin, Germany)
|March 24, 2023
Summary
Endocrine therapy (ET) treats tumors by altering hormone levels. This review explores ET drugs, their link to ubiquitination, and clinical applications of ET combined with ubiquitination for overcoming treatment resistance.
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- Endocrine therapy (ET) regulates hormone levels to treat tumors, but resistance develops due to abnormal hormone receptor accumulation and mutations.
- Ubiquitination-mediated targeted protein degradation is crucial for regulating intracellular protein levels and functions in eukaryotes.
Purpose of the Study:
- To review traditional and novel endocrine therapy drugs.
- To elucidate the connection between ubiquitination and endocrine therapy.
- To discuss the clinical utility of combining ET with ubiquitination-related molecules.
Main Methods:
- Literature review of endocrine therapy drugs.
- Exploration of the molecular mechanisms linking ubiquitination to ET resistance.
- Analysis of clinical studies on combined ET and ubiquitination-based treatments.
Main Results:
- Identified various traditional and novel ET drugs.
- Established the role of ubiquitination in regulating hormone receptor levels and function.
- Highlighted the potential of combining ET with ubiquitination strategies to enhance treatment efficacy.
Conclusions:
- Ubiquitination plays a critical role in endocrine therapy resistance and offers therapeutic targets.
- Combining ET with ubiquitination-related molecules presents a promising strategy for overcoming treatment resistance in cancer therapy.
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