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Effect of miconazole on growth and aflatoxin production by Aspergillus parasiticus
R L Buchanan1, S B Jones, H G Stahl
1Eastern Regional Research Center, USDA, Philadelphia, PA 19118.
Mycopathologia
|December 1, 1987
Abstract:
At 5 microM, miconazole prevented the growth of Aspergillus parasiticus Speare in a number of media. Sensitivity to miconazole was increased approximately 10-fold in a medium containing glycerol. At sub-inhibitory concentrations, miconazole stimulated aflatoxin synthesis on media which normally support toxin formation. Miconazole inhibited respiration and altered mitochondrial ultrastructure, suggesting that miconazole inhibits growth and stimulates aflatoxin production by depressing mitochondrial activity.