Related Experiment Videos
Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic
S Kaul1, D D Watson, J D Oliner
1Department of Medicine, University of Virginia School of Medicine, Charlottesville.
Insights
Plasma clearance of 169Yb-DTPA effectively tracks left ventricular systolic function and myocardial damage in dogs with ischemic dysfunction. This method shows promise for assessing cardiac health, correlating well with cardiac output and infarct size.
Area of Science:
- Cardiology
- Renal Physiology
- Experimental Medicine
Background:
- Assessing left ventricular systolic function is crucial for diagnosing and managing heart conditions.
- Glomerular filtration rate (GFR) is a key indicator of kidney function and can be influenced by cardiac output.
Purpose of the Study:
- To investigate the correlation between the plasma clearance of 169Yb-DTPA and left ventricular systolic function in a canine model.
- To determine if 169Yb-DTPA clearance can serve as a non-invasive marker for myocardial dysfunction and infarct size.
Main Methods:
- Serial measurements of 169Yb-DTPA plasma clearance were performed in anesthetized open-chest dogs.
- Two groups were studied: normal left ventricular function (Group I) and ischemic left ventricular dysfunction (Group II).
- Cardiac output, mean arterial pressure, and myocardial contrast echocardiography were utilized to assess hemodynamic parameters and infarct size.
Main Results:
- In dogs with ischemic left ventricular dysfunction, 169Yb-DTPA clearance changes correlated significantly with changes in cardiac output (r=0.80) and area at risk for necrosis (r=-0.93).
- 169Yb-DTPA clearance remained constant in dogs with normal left ventricular function.
- No significant correlation was found between 169Yb-DTPA clearance changes and mean arterial pressure (r=0.26).
Conclusions:
- Plasma clearance of 169Yb-DTPA is a reliable indicator of left ventricular systolic function and infarct size in the setting of ischemic dysfunction.
- Changes in 169Yb-DTPA clearance reflect alterations in cardiac output and myocardial damage.
- 169Yb-DTPA clearance is not influenced by mean arterial pressure in this model.
Unlabelled:
Plasma clearance of 169Yb-DTPA, a heavy chelate metal excreted only by glomerular filtration, was measured serially in a canine model to determine whether the clearance of this substance correlates with left ventricular systolic function. Fourteen anesthetized open-chest dogs were studied. Six dogs (group I) were used to estimate the clearance of 169Yb-DTPA in the setting of normal left ventricular function. Eight dogs (group II) were used to estimate clearance of 169Yb-DTPA in the presence of ischemic left ventricular dysfunction. Cardiac output, mean arterial pressure, and plasma levels of 169Yb-DTPA were measured serially. In group II dogs, area at risk for necrosis was defined using myocardial contrast echocardiography. The change in clearance of 169Yb-DTPA in group II dogs correlated well with change in cardiac output and area at risk (r = 0.80 and -0.93, respectively) and was significantly different from group I dogs (p less than 0.01). However, changes in clearance of 169Yb-DTPA in the group II dogs did not correlate well with change in mean arterial pressure (r = 0.26).
In Conclusion:
(1) clearance of 169Yb-DTPA is constant over time in the absence of ischemic left ventricular dysfunction and derangement of other hemodynamic parameters; (2) changes in clearance of 169Yb-DTPA correlate well with changes in systolic pump function and left ventricular area at risk in the setting of ischemic left ventricular dysfunction, and (3) clearance of 169Yb-DTPA is not related to mean arterial pressure.