Activatable fluorescent probes for real-time imaging-guided tumor therapy

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Nanotechnology

Background:

• Cancer treatment relies on surgery and drugs, but accurate tumor localization and treatment monitoring remain challenging.
• Conventional imaging techniques have limitations in spatial resolution and real-time feedback for cancer care.
• Fluorescence imaging offers high resolution, real-time capabilities, and cost-effectiveness for tumor diagnosis and treatment evaluation.

Purpose of the Study:

• To review recent advancements in activatable fluorescent probes for cancer diagnosis and therapy.
• To highlight the potential of activatable nanoprobes in fluorescence imaging-guided surgery.
• To discuss the application of activatable nanoprobes in imaging-guided drug therapy.

Main Methods:

• Review of recent literature on fluorescent probes, focusing on site-specifically activatable probes.
• Analysis of small molecule probes and nanoparticle-based probes for tumor imaging.
• Exploration of activatable nanoprobes for surgical guidance and drug therapy monitoring.

Main Results:

• Site-specifically activatable fluorescent probes enable precise tumor delineation.
• Activatable nanoprobes provide real-time feedback on drug therapy efficacy.
• These probes enhance the capabilities of fluorescence imaging in oncology.

Conclusions:

• Activatable fluorescent nanoprobes are crucial for advancing fluorescence imaging in oncology.
• They show significant potential for improving fluorescence imaging-guided surgery and drug therapy.
• Further development of these nanoprobes can revolutionize cancer treatment strategies.