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A population-based cohort study on risk factors for acute pancreatitis: A comparison by age group
Jin Myung Park1, Namyoung Park2, Sang Hyub Lee3
1Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, South Korea.
Insights
Acute pancreatitis (AP) risk factors and incidence vary significantly by age group. Understanding these differences is key for developing targeted prevention strategies for young, middle-aged, and older adults.
Area of Science:
- Gastroenterology
- Epidemiology
- Public Health
Background:
- Acute pancreatitis (AP) is an inflammatory condition affecting all ages, with risk increasing with age.
- Previous studies have not compared AP risk factors across different age demographics.
- This study addresses the gap by comparing AP risk factors by age group.
Purpose of the Study:
- To compare the incidence and risk factors of first-attack acute pancreatitis (AP) across distinct age groups.
- To identify age-specific risk factors for AP to inform tailored prevention strategies.
Main Methods:
- Analysis of health examination data from 4,238,822 individuals aged 20+ in South Korea (2009).
- Identification of first-attack AP using claims data from 2009 to 2018.
- Stratified analysis of AP incidence and risk factors in young (20-39), middle-aged (40-64), and old (65+) groups.
Main Results:
- AP incidence increased with age: 16.30 (young), 27.85 (middle-aged), and 57.19 (old) per 100,000 person-years.
- Smoking, alcohol, diabetes, gallstones, and chronic pancreatitis were universal risk factors.
- Hypertension and dyslipidemia increased AP risk in younger and middle-aged groups, while high income showed a protective effect in these demographics. Male sex, older age, and higher waist circumference were risk factors in middle-aged and older adults.
Conclusions:
- AP incidence and associated risk factors demonstrate significant variation across age groups.
- Age-specific prevention strategies are necessary for effective AP management.
- This population-based study highlights the need for tailored public health interventions for AP prevention.
Background:
/objectives: Acute pancreatitis (AP) is an acute inflammatory disorder that can occur in all age groups. The risk of AP has been shown to increase with age. However, no study has compared risk factors for AP according to age group yet. Thus, the aim of this study was to perform such comparison.
Methods:
Clinical data from individuals 20 years of age and older who received a health examination arranged by the Korean national health insurance program in 2009 (n = 4,238,822) were used. First-attack AP was identified using claims data from baseline to December 2018. Incidence and risk factors of AP were analyzed for young (20-39 years old), middle-aged (40-64 years old), and old (over 65 years old) groups.
Results:
Incidences of AP in young, middle-aged, and old groups were 16.30, 27.85, and 57.19 per 100,000 person-years, respectively. Smoking, alcohol drinking, diabetes, gallstone, and chronic pancreatitis were associated with increased risk of AP in all age groups. Meanwhile, male, older age, and higher waist circumference were associated with increased risk of AP in middle-aged and old groups. In young and middle-aged groups, risk of AP was increased in the presence of hypertension and dyslipidemia. However, high income was associated with decreased risk of AP in these groups.
Conclusions:
In this population-based cohort study, incidences and risk factors for AP differed according to age group. Thus, a tailored strategy might be needed to prevent AP according to age group.
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