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Sideways: road to gene-by-gene functional screening in malaria parasites
Thanat Chookajorn1, Oliver Billker2
1Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå 90187, Sweden; Department of Molecular Biology, Umeå University, Umeå 90187, Sweden; Genomics and Evolutionary Medicine Unit (GEM), Centre of Excellence in Malaria Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Abstract:
Genome-wide screening in apicomplexan species has transformed our understanding of these parasitic protozoa. Kimmel et al. report a 'knock sideways' system and provide a powerful use case for its feasibility in a gene-by-gene screening in Plasmodium falciparum. Carefully deployed, a novel toolkit helps to dissect the biological uniqueness of an important parasite.
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