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Perspectives on the Wetting of Solids in Pharmaceutical Systems
1Seventh Street Development Group, PO Box 251, Kure Beach, NC, 24889, 765-650-4462, USA. ann.newman@seventhstreetdev.com.
Pharmaceutical Research
|March 25, 2023
Summary
Understanding pharmaceutical solid wettability is key for drug development. Surface properties like energetics, heterogeneities, and pore structure significantly influence how well drug formulations interact with water.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Physical Chemistry
Background:
- Wettability of pharmaceutical solids by water is crucial for solid dosage form processing and administration.
- Nonpolar pharmaceutical solids present challenges in achieving adequate wetting.
Purpose of the Study:
- To review and analyze factors influencing the wettability of pharmaceutical solids.
- To emphasize the thermodynamic principles and practical considerations for improving wettability.
Main Methods:
- Thermodynamic analysis of liquid surface tension and solid surface energetics.
- Evaluation of contact angle and solid surface polarity.
- Analysis of various factors affecting surface energetics and structure.
Main Results:
- Ideal wettability depends on liquid surface tension and solid surface energetics (contact angle, polarity).
- Crystal defects, polymorphism, amorphous structures, surface roughness, and pore complexity significantly alter surface energetics.
- Case studies demonstrated wettability in single, binary, and multicomponent pharmaceutical systems.
Conclusions:
- Modifying solid surface energetics, chemical/physical heterogeneities, and pore structure is essential for enhancing pharmaceutical wettability.
- A comprehensive understanding of these factors is critical for successful drug formulation development.
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