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Updated: Aug 5, 2025
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer
Maryam Nurzadeh1, Seyedeh Mojgan Ghalandarpoor-Attar2, Seyedeh Noushin Ghalandarpoor-Attar3
1Fetomaternal Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
Ovarian cancer (OC) is the most deadly tumor that may develop in a woman's reproductive system. It is also one of the most common causes of death among those who have been diagnosed with cancer in women. An adapter protein known as sequestosome 1(SQSTM1) or p62 is primarily responsible for the transportation, degradation, and destruction of a wide variety of proteins. This adapter protein works in conjunction with the autophagy process as well as the ubiquitin proteasome degradation pathway. In addition, the ability of SQSTM1 to interact with multiple binding partners link SQSTM1 to various pathways in the context of antioxidant defense system and inflammation. In this review, we outline the processes underlying the control that SQSTM1 has on these pathways and how their dysregulation contributes to the development of OC. At the final, the therapeutic approaches based on SQSTM1 targeting have been discussed.
Insights
Sequestosome 1 (SQSTM1) protein regulates pathways involved in ovarian cancer (OC) development. Targeting SQSTM1 offers potential new therapeutic strategies for this deadly gynecologic malignancy.
Area of Science:
- Oncology
- Molecular Biology
- Cellular Biology
Background:
- Ovarian cancer (OC) is a leading cause of cancer death in women.
- Sequestosome 1 (SQSTM1), also known as p62, is an adapter protein crucial for protein degradation via autophagy and the ubiquitin-proteasome system.
- SQSTM1 interacts with multiple partners, linking it to critical cellular processes like inflammation and antioxidant defense.
Purpose of the Study:
- To review the role of SQSTM1 in regulating pathways implicated in ovarian cancer.
- To explore how dysregulation of SQSTM1-mediated pathways contributes to OC development.
- To discuss potential therapeutic strategies targeting SQSTM1 for ovarian cancer treatment.
Main Methods:
- Literature review of studies on SQSTM1 function in cellular pathways.
- Analysis of the link between SQSTM1, inflammation, and antioxidant defense in cancer.
- Review of current and emerging therapeutic approaches targeting SQSTM1.
Main Results:
- SQSTM1 plays a significant role in controlling inflammatory and antioxidant pathways.
- Dysregulation of these SQSTM1-controlled pathways is associated with ovarian cancer progression.
- Targeting SQSTM1 presents a promising avenue for novel OC therapies.
Conclusions:
- SQSTM1 is a key regulator of cellular processes that, when dysregulated, contribute to ovarian cancer.
- Modulating SQSTM1 activity holds therapeutic potential for managing ovarian cancer.
- Further research into SQSTM1-targeted therapies is warranted for effective OC treatment.
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