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Updated: Aug 5, 2025

Modeling Human Cerebellar Development In Vitro in 2D Structure
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Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

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Longitudinal development of the cerebellum in human infants during the first 800 days

Ya Wang1, Liangjun Chen2, Zhengwang Wu2

  • 1National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Cell Reports
|March 25, 2023
PubMed

Insights

Early cerebellar development, crucial for understanding neurodevelopmental disorders, shows rapid growth peaking around 13 months. Specific lobule volumes correlate with fine motor skills in infants.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Radiology

Background:

  • Understanding early cerebellar development is key to identifying neurodevelopmental disorders.
  • Infant-tailored neuroimaging techniques are essential for studying early brain development.

Purpose of the Study:

  • To investigate the dynamic volumetric development of the cerebellum and its sub-regions in infants.
  • To explore the relationship between cerebellar development and behavioral scores.

Main Methods:

  • Utilized infant-tailored cerebellar image processing techniques.
  • Analyzed 511 high-resolution structural MRI scans from the first 800 postnatal days.
  • Tracked volumetric trajectories of the cerebellum and 27 sub-regions.

Main Results:

  • Cerebellum-to-intracranial volume ratio rapidly increases, peaking at 13 months.
  • Most cerebellar sub-regions show initial rapid volume increase, followed by a slight decrease (except X lobules).
  • Males exhibit larger absolute lobule volumes than females; cerebellar development correlates positively with fine motor skills.

Conclusions:

  • Early cerebellar volumetric development follows distinct trajectories, with sex-based differences observed.
  • Specific lobule development, particularly Crus I and II, is linked to emerging fine motor skills.
  • This research provides normative data crucial for diagnosing pediatric neurodevelopmental disorders.

Keywords:
CP: NeuroscienceMRIdevelopmental trajectoryinfant cerebellumpercentile scorevolumetric development

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