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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: Aug 5, 2025

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Nanomedicine for T-Cell Mediated Immunotherapy.

Fangzhou Li^1,2, Jiang Ouyang¹, Zuqin Chen²

¹Department of Minimally Invasive Interventional Radiology, the State Key Laboratory of Respiratory Disease, School of Biomedical Engineering & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)

|March 25, 2023

Summary

Nanomedicines enhance T-cell immunotherapy by addressing challenges like immune suppression and T-cell loss. This approach shows promise for treating various diseases, including cancers and autoimmune conditions.

Keywords:

T cells autoimmune diseases biomimetic materials cancer immunotherapy nanomedicines

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Area of Science:

Immunology
Nanotechnology
Biomedical Engineering

Background:

T-cell immunotherapy shows promise but has limited patient benefit due to challenges like immune suppression and T-cell viability.
Current strategies face hurdles including maintaining T-cell balance, overcoming disease microenvironment suppression, and preventing target loss.

Purpose of the Study:

To explore how nanomedicines can be adapted with nanomaterials to improve T-cell immunotherapy efficacy.
To review recent advances in nanomedicine for T-cell immunotherapy in various diseases.

Main Methods:

Review of nanomedicine strategies applied to T-cell immunotherapy.
Summary of nanomedicine applications in immunosuppressive and immune-activated pathological states.
Focus on diseases including cancers, rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis, and diabetes.

Main Results:

Nanomedicines offer diversity, flexibility, and intelligence to enhance T-cell immunotherapy.
Specific examples of nanomedicine applications in various diseases are discussed.
Nanomaterials can be tailored to overcome challenges in T-cell immunotherapy.

Conclusions:

Nanomedicines hold significant potential for improving T-cell immunotherapy outcomes.
Tailoring nanomaterials can enhance therapeutic efficacy in conditions like cancer and autoimmune diseases.
This review advances understanding of nanotechnology's role in optimizing T-cell immunotherapy.