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Updated: Aug 5, 2025

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Published on: July 15, 2019

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Epithelial salivary gland tumors in pediatric patients: An international collaborative study

Gabriella Alves Quixabeira Oliveira1, Maria Eduarda Pérez-DE-Oliveira1, Liam Robinson2

  • 1Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.

International Journal of Pediatric Otorhinolaryngology
|March 25, 2023
PubMed

Insights

Pediatric salivary gland tumors (SGT) are rare, with pleomorphic adenoma and mucoepidermoid carcinoma being most common. Most SGT in children are benign, often presenting as painless nodules.

Area of Science:

  • Pediatric Oncology
  • Head and Neck Surgery
  • Pathology

Background:

  • Salivary gland tumors (SGT) are uncommon neoplasms, particularly in pediatric populations.
  • Characterizing SGT in children is crucial due to their rarity and diverse clinical presentations.

Purpose of the Study:

  • To define the clinicopathological profile of pediatric SGT using a large international case series.
  • To analyze the clinical characteristics and diagnostic associations of SGT in patients aged 0-19 years.

Main Methods:

  • Retrospective analysis of 203 pediatric SGT cases diagnosed between 2000-2021.
  • Data collected from academic centers in Brazil, South Africa, and the United Kingdom.
  • Quantitative and descriptive statistical analysis of clinicopathological data.

Main Results:

  • The palate (43.5%) and parotid gland (29%) were the most frequent tumor sites.
  • Pleomorphic adenoma (58.6%) was the most common SGT, followed by mucoepidermoid carcinoma (26.6%).
  • Most SGT presented as flesh-colored, smooth, painless nodules, with surgery being the primary treatment (90.8%).

Conclusions:

  • Pediatric salivary gland tumors are predominantly benign.
  • Pleomorphic adenoma and mucoepidermoid carcinoma are key considerations for nodular lesions of salivary gland origin in children.
Abstract

Keywords:
AdolescentChildrenEpidemiologyHead and neck cancerSalivary glands tumorsSurvival

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