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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
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Basic research on curcumin in cervical cancer: Progress and perspectives.

Xiaoyu Zhang1, Lin Zhu1, Xuezhen Wang1

  • 1School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 25, 2023
PubMed
Summary

Curcumin, a natural compound, shows promise in fighting cervical cancer by promoting cell death and inhibiting tumor growth. Further research into curcumin derivatives is needed to overcome bioavailability challenges for clinical use.

Keywords:
Cervical cancerCurcuminMechanismPathwayPlants

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Area of Science:

  • Pharmacology
  • Oncology
  • Natural Products

Background:

  • Cervical cancer remains a significant global health challenge, particularly in low-income populations.
  • Curcumin, a polyphenol from turmeric, exhibits diverse pharmacological effects including anti-inflammatory and anti-tumor properties.
  • While HPV vaccination is crucial, its limited accessibility necessitates alternative therapeutic strategies.

Purpose of the Study:

  • To systematically review the mechanisms by which curcumin exerts anti-cervical cancer effects.
  • To explore curcumin's potential as a novel therapeutic agent for cervical cancer.
  • To identify research gaps and provide insights for future scientific and clinical endeavors.

Main Methods:

  • Literature review of in vitro and in vivo studies on curcumin and cervical cancer.
  • Analysis of curcumin's effects on cancer cell apoptosis, proliferation, metastasis, and invasion.
  • Examination of curcumin's impact on human papillomavirus (HPV) and autophagy in tumor cells.

Main Results:

  • Curcumin demonstrates efficacy by promoting apoptosis, inhibiting tumor cell proliferation, metastasis, and invasion.
  • Curcumin has shown potential in inhibiting HPV and inducing autophagy within tumor cells.
  • Studies highlight the need for improved curcumin derivatives and formulations due to poor solubility and bioavailability.

Conclusions:

  • Curcumin possesses a broad spectrum of anti-cervical cancer mechanisms.
  • Curcumin holds potential as a future antitumor drug, offering novel therapeutic avenues.
  • This review provides a comprehensive overview of curcumin's action against cervical cancer, aiding researchers and clinicians.