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Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Updated: Aug 5, 2025

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology

Published on: June 10, 2014

Current advancements in bio-ink technology for cartilage and bone tissue engineering.

Ravindra V Badhe¹, Abhinav Chatterjee², Divya Bijukumar²

¹Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL, USA; Pharmaceutical Chemistry Department, Marathwada Mitramandal's College of Pharmacy, Thergaon, Pune, Maharashtra, India.

|March 25, 2023

Summary

This review explores biomaterials for 3D printing bone and cartilage tissues. It details bio-ink requirements, processing, and cell compatibility for orthopedic and orthodontic applications.

Keywords:

3D printing Bio-ink Biomaterials Drug delivery for bone tissue Regenerative medicine Tissue engineering

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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

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Last Updated: Aug 5, 2025

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology

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Published on: June 10, 2014

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Area of Science:

Tissue Engineering
Biomaterials Science
Additive Manufacturing

Background:

Tissue regeneration relies on 3D architecture, cells, and stimuli.
3D bio-printing, utilizing Computer-Aided Design (CAD), enables precise structure development.
Bio-inks are crucial for cell support, proliferation, drug delivery, and shape in 3D printing.

Purpose of the Study:

To review biomaterials used for 3D printing bone and cartilage.
To discuss processing variables, cell-seeding densities, and bio-ink requirements.
To highlight applications in orthopedics and orthodontics.

Main Methods:

Literature review of biomaterials for bone and cartilage bio-inks.
Analysis of processing variables and cell-seeding densities.
Evaluation of bio-ink advantages, limitations, and cell compatibility.

Main Results:

Identified various biomaterials suitable for bone and cartilage bio-inks.
Discussed critical performance and architectural morphology requirements.
Compiled information on cell-bio-ink compatibility.

Conclusions:

Selection of appropriate bio-inks is critical for successful 3D printing of bone and cartilage.
Understanding biomaterial properties and processing is key for orthopedic and orthodontic applications.
Further research into bio-ink development is needed to mimic natural tissue strength and function.