Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Warm ischemic time-dependent effects on oxidative stress, endoplasmic reticulum stress, and inflammation in cold storage human donor hearts.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Administration of a novel reprogramming formula improves cardiac function and decreases cardiac fibrosis in a myocardial infarction model.

JTCVS open·2025
Same author

The state of educational research in cardiothoracic surgery: A review of the literature.

JTCVS open·2025
Same author

Brain death versus circulatory death: how functional warm ischemia and cold storage impact myocardial membrane repair in human donor hearts.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis.

Nature biomedical engineering·2025
Same author

Effect of cold storage solution on warm ischemia-induced myocardial plasma membrane damage and pyroptosis in human hearts from circulatory death donors.

The Journal of thoracic and cardiovascular surgery·2025

Related Experiment Video

Updated: Aug 5, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K

Direct cardiac reprogramming: A new technology for cardiac repair.

Paige E Brlecic1, Clark A Bonham1, Todd K Rosengart1

  • 1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.

Journal of Molecular and Cellular Cardiology
|March 25, 2023
PubMed
Summary

Cardiac reprogramming offers a novel therapeutic approach to regenerate heart tissue damaged by cardiovascular disease. This method converts scar tissue cells into new heart muscle cells, potentially improving patient outcomes.

More Related Videos

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter
05:04

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

3.5K
Assessing Cardiac Reprogramming using High Content Imaging Analysis
06:02

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Published on: October 26, 2020

1.3K

Related Experiment Videos

Last Updated: Aug 5, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K
In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter
05:04

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

3.5K
Assessing Cardiac Reprogramming using High Content Imaging Analysis
06:02

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Published on: October 26, 2020

1.3K

Area of Science:

  • Cardiovascular Science
  • Regenerative Medicine
  • Cellular Biology

Background:

  • Cardiovascular disease (CVD) is a major global cause of death, with myocardial infarctions leading to significant cardiac tissue damage.
  • Current treatments manage metabolic risk factors but do not regenerate damaged heart muscle.
  • Increasing lifespans heighten the risk for CVD, necessitating advanced therapeutic strategies.

Purpose of the Study:

  • To review the historical development and recent advancements in cardiac reprogramming.
  • To explore the potential of transdifferentiation for treating cardiovascular disease.
  • To highlight the translational prospects of reprogramming fibrotic cells into induced cardiomyocytes.

Main Methods:

  • Review of scientific literature on cellular reprogramming and cardiac repair.
  • Analysis of studies focusing on transdifferentiation of cardiac fibroblasts into cardiomyocytes.
  • Examination of the challenges and successes in preclinical and clinical research.

Main Results:

  • Transdifferentiation and cellular reprogramming are promising avenues for disease treatment.
  • Reprogramming cardiac scar tissue cells (fibroblasts) into induced cardiomyocytes is a key strategy.
  • Significant progress has been made in understanding and applying cardiac reprogramming techniques.

Conclusions:

  • Cardiac reprogramming presents a potential paradigm shift in treating heart damage.
  • Targeting fibrotic cells for reprogramming offers a regenerative approach beyond current pharmacotherapies.
  • Further research is crucial to translate these findings into effective clinical treatments for cardiovascular disease.