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Related Experiment Video

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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
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Cerebrovascular Reactivity and Concussion.

Erin T Wong1, Anish Kapadia1, Venkatagiri Krishnamurthy2

  • 1Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; Department of Medical Imaging, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Neuroimaging Clinics of North America
|March 25, 2023
PubMed
Summary

Cerebrovascular reactivity (CVR) testing reveals faster and stronger blood flow responses in acute concussion patients. These unique CVR changes show potential for diagnosing concussion in individuals.

Keywords:
Cerebral blood flowCerebrovascular reactivityConcussionTraumatic brain injury

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Area of Science:

  • Neurology
  • Physiology
  • Medical Diagnostics

Background:

  • Cerebrovascular reactivity (CVR) assesses cerebral vasculature health by measuring blood flow changes to stimuli.
  • Quantitative CO2 delivery methods allow detailed mapping of CVR speed and magnitude.

Purpose of the Study:

  • To investigate CVR patterns in acute concussion patients.
  • To evaluate the diagnostic potential of CVR alterations in concussion.

Main Methods:

  • Utilized computer-controlled sequential gas delivery for precise CO2 stimuli.
  • Measured the speed and magnitude of cerebral blood flow responses in patients.

Main Results:

  • Acute concussion patients exhibited unexpectedly faster and greater CVR responses compared to other conditions.
  • CVR alterations demonstrated significant diagnostic potential with AUC values of 0.90-0.94.

Conclusions:

  • CVR testing reveals distinct physiological patterns in acute concussion.
  • Quantified CVR alterations offer a promising diagnostic tool for individual concussion assessment.