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Updated: Aug 5, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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The function and mechanisms of action of circular RNAs in Urologic Cancer

Zi-Hao Zhang1,2,3, Yue Wang2,3, Ya Zhang4

  • 1Qingdao Institute, School of Life Medicine, Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Qingdao, 266500, China.

Molecular Cancer
|March 25, 2023
PubMed

Insights

Circular RNAs (CircRNAs) are key players in urologic cancers, impacting tumor growth and spread. This review explores their potential as diagnostic biomarkers and therapeutic targets for kidney, bladder, and prostate cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Urologic cancers, including kidney, bladder, and prostate cancer, pose significant health risks.
  • Circular RNAs (CircRNAs) are unique non-coding RNAs with diverse biological functions.
  • Aberrant CircRNA expression is linked to the pathogenesis of urologic malignancies.

Purpose of the Study:

  • To review the properties and biological functions of CircRNAs.
  • To elucidate the role of CircRNAs in the development of kidney, bladder, and prostate cancers.
  • To highlight the potential of CircRNAs as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies on CircRNAs in urologic cancers.
  • Analysis of CircRNA functions including microRNA sponging, protein binding, and transcriptional regulation.
  • Focus on CircRNA involvement in cancer proliferation, metastasis, apoptosis, metabolism, and drug resistance.

Main Results:

  • CircRNAs exhibit critical roles in regulating key cancer hallmarks.
  • Abnormal CircRNA expression is a common feature in urologic tumors.
  • CircRNAs demonstrate potential as diagnostic and prognostic indicators.

Conclusions:

  • CircRNAs are emerging as significant factors in urologic oncology.
  • Further research into CircRNAs could lead to novel diagnostic and therapeutic strategies for kidney, bladder, and prostate cancers.
Keywords:
And prostate cancerBladder cancerCircRNAKidney cancer

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