Diagnostic value of echocardiography combined with serum C-reactive protein level in chronic heart failure
1Cardiovascular Medicine Department, The Third Affiliated Hospital of Guangzhou Medical University, No.63 Duobao Road, Liwan District, Guangzhou, 510150, Guangdong Province, China. YongxiaZhang0315@163.com.
Insights
Echocardiography (Echo) and C-reactive protein (CRP) levels effectively diagnose chronic heart failure (CHF). Combining these methods offers high clinical diagnostic value for identifying CHF patients.
Area of Science:
- Cardiology
- Biomarkers
- Diagnostic Imaging
Background:
- Chronic heart failure (CHF) is a prevalent cardiovascular condition.
- Accurate diagnosis is crucial for effective management.
- Current diagnostic methods require enhancement for improved accuracy.
Purpose of the Study:
- To evaluate the diagnostic utility of echocardiography (Echo) and serum C-reactive protein (CRP) in patients with CHF.
- To assess the combined diagnostic value of Echo parameters and CRP levels.
- To identify independent risk factors for CHF.
Main Methods:
- Enrolled 75 CHF patients and 70 controls.
- Measured left ventricular ejection fraction (LVEF), fraction shortening (FS), and E/A ratio via Echo.
- Quantified serum CRP levels using ELISA.
- Analyzed correlations using Pearson method and diagnostic efficacy via ROC curves.
- Identified risk factors using logistic regression.
Main Results:
- CHF patients exhibited elevated CRP, decreased LVEF and FS, and increased E/A ratios.
- Combined Echo parameters (LVEF, FS, E/A) and CRP showed high diagnostic value for CHF.
- Echo parameters and CRP levels were identified as independent risk factors for CHF.
Conclusions:
- Echocardiography combined with serum CRP levels demonstrates significant clinical diagnostic value for CHF.
- This combined approach offers a robust method for diagnosing chronic heart failure.
- Further research may explore the integration of these markers in routine clinical practice.
Background:
Chronic heart failure (CHF) is regarded as common clinical heart disease. This study aims to investigate the clinical diagnostic value of echocardiography (Echo) and serum C-reactive protein (CRP) levels in patients with CHF.
Methods:
A total of 75 patients with CHF (42 males, 33 females, age 62.72 ± 1.06 years) were enrolled as study subjects, with 70 non-CHF subjects (38 males, 32 females, age 62.44 ± 1.28 years) as controls. The left ventricular ejection fraction (LVEF), fraction shortening rate of the left ventricle (FS), and early to late diastolic filling (E/A) were determined by Echo, followed by an examination of the expression of serum CRP by ELISA. In addition, the Pearson method was used to analyze the correlation between echocardiographic quantitative parameters (EQPs) (LVEF, FS, and E/A) and serum CRP levels. Receiver operating characteristic (ROC) curve was adopted to evaluate the diagnostic efficacy of EQPs and serum CRP levels for CHF. The independent risk factors for CHF patients were measured by logistics regression analysis.
Results:
The serum CRP level of CHF patients was elevated, the values of LVEF and FS decreased, and the E/A values increased. ROC curve revealed that the EQPs (LVEF, FS, and E/A) combined with serum CRP had high diagnostic values for CHF patients. Logistic regression analysis showed that the EQPs (LVEF, FS, and E/A) and serum CRP levels were independent risk factors for CHF patients.
Conclusion:
Echo combined with serum CRP level has high clinical diagnostic values for CHF patients.
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