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Treatments and challenges in advanced prostate cancer

Theodore Gourdin1, Arash Velayati

  • 1Department of Medicine - Division of Hematology Oncology, Medical University of South Carolina, Charleston, South Carolina, USA.

Current Opinion in Oncology
|March 26, 2023
PubMed
Abstract

Insights

New treatments offer survival benefits for advanced prostate cancer patients. However, selecting the optimal therapy and addressing challenges like neuroendocrine differentiation require further research.

Area of Science:

  • Oncology
  • Urology
  • Medical Research

Background:

  • Advanced prostate cancer treatment has seen significant progress.
  • Identifying optimal therapeutic strategies for metastatic disease remains a challenge.

Approach:

  • This review synthesizes recent research on advanced prostate cancer treatments.
  • It highlights advancements and persistent challenges in clinical outcomes.

Key Points:

  • Triplet therapy (androgen deprivation, docetaxel, androgen receptor axis-targeted agent) shows survival advantage in some metastatic prostate cancer patients.
  • Prostate-specific membrane antigen (PSMA)-radiopharmaceuticals and novel androgen receptor axis manipulations offer additional treatment success.
  • Challenges include therapy selection, harnessing immunotherapy, and managing neuroendocrine differentiation.

Conclusions:

  • The increasing availability of therapeutics improves outcomes but complicates treatment selection.
  • Continued research is essential to refine treatment paradigms for advanced prostate cancer.

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