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Published on: January 7, 2018
Studies are needed to support optimal insulin dose titration in gestational diabetes mellitus: A systematic review
Isabelle K Mayne1, Henry M Tyzack-Clark2, Andrew P McGovern3
1University of Exeter Medical School, Exeter, UK.
Background And Aims:
We aimed to summarise the existing literature on insulin dose titration in gestation diabetes.
Methods:
Databases: Medline, EMBASE, CENTRAL and CINAHL were systematically searched for trials and observational studies comparing insulin titration strategies in gestational diabetes.
Results:
No trials comparing insulin dose titration strategies were identified. Only one small (n = 111) observational study was included. In this study, patient-led daily basal insulin titration was associated with higher insulin doses, tighter glycaemic control, and lower birthweight, vs weekly clinician-led titration.
Conclusions:
There is a paucity of evidence to support optimal insulin titration in gestational diabetes. Randomized trials are required.
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