Discretizing the cellular bases of plant morphogenesis: Emerging properties from subcellular and noisy patterning

A fundamental question in biology is how multicellular organisms robustly shape their organs. In the past decade, much progress has been made not just in identifying biochemical and biophysical factors underpinning morphogenesis, but also in analyzing their spatio-temporal dynamics. A remarkable outcome of such analyses is that morphogenesis involves high levels of heterogeneity and fluctuations at local scales. Although this could be considered as white noise to be averaged over time, there is increasing evidence that these heterogeneities and fluctuations are instructive cues for development. In this review, we highlight some of the new questions that such heterogeneities raise for plant morphogenesis. We also investigate their effects across scales, focusing on how subcellular heterogeneities contribute to organ shape robustness and evolvability.