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Changes in choroidal thickness in myopic children with 0.01% atropine: Evidence from a 12-month follow-up
Jianhua Wu1, Hui Gong1, Huixia Li1
1Department of Ophthalmology, Inner Mongolia Chaoju Eye Hospital, 010050 Hohhot, China.
Insights
Low-dose atropine eye drops significantly increased choroidal thickness (ChT) in myopic children after three months. This thickening effect persisted for twelve months and may relate to central cornea thickness changes.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Myopia Control
Background:
- Myopia is a growing public health concern in children.
- Choroidal thickness (ChT) is a potential indicator of myopia progression.
- Low-dose atropine is increasingly used for myopia management.
Purpose of the Study:
- To evaluate the effect of 0.01% low-dose atropine on choroidal thickness (ChT) in children with low myopia.
- To assess changes in ChT over a 12-month period.
- To explore potential associations between ChT changes and ocular biometry.
Main Methods:
- A prospective study involving 25 children with low myopia.
- Participants received 0.01% atropine eye drops nightly for 12 months.
- Choroidal thickness and ocular biometry were measured at baseline and at 1, 3, 6, and 12 months.
Main Results:
- Subfoveal choroidal thickness significantly increased by 3 months (p<0.0001) and continued to thicken up to 12 months.
- The increase in ChT from baseline to 3 months was significantly greater than from baseline to 1 month (p<0.0001).
- A significant association was found between subfoveal ChT changes and central cornea thickness (CCT) changes (p=0.045).
Conclusions:
- Low-dose atropine (0.01%) effectively increases subfoveal choroidal thickness in myopic children.
- The observed increase in ChT is sustained for at least 12 months.
- Changes in subfoveal ChT may be linked to alterations in central cornea thickness.
Purpose:
To investigate the changes of low-dose atropine (0.01%) on the choroidal thickness (ChT) of young children with low myopia.
Methods:
A total of 25 eyes of 25 low myopic children were included. All subjects were prescribed 0.01% atropine eye drops to be applied once per night before bedtime in involving eyes. The ChT and ocular biometry parameters were measured before and after 1 month, 3 months, 6 months and 12 months. The children were followed up for 12 months.
Results:
At 3 months, the ChT under the fovea significantly increased (309.96±70.82 μm) in comparison with the baseline (297.92±66.31 μm, P<0.0001) and was continuous thickening till 12 months after treatments with 0.01% atropine. Similarly, the changes of ChT under the fovea significantly increased from baseline to 3 months in comparison with the baseline to 1 month after treatments (P<0.0001). There was a significant relationship between changes in subfoveal ChT and central cornea thickness (CCT, beta=-1.76, 95% confidence intervals: -3.49 to -0.04, P = 0.045).
Conclusions:
Using low dose atropine eye drops significantly increased subfoveal ChT after 3 months in eyes of myopic children. In addition, the changes in subfoveal ChT may be associated with the changes of CCT.
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