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The role of irisin and asprosin level in the pathophysiology of prediabetes
Gokcen Nailer Ertuna1, Enes Seyda Sahiner1, Fatma Meric Yilmaz2
1Health Sciences University, Ankara City Hospital, Department of Internal Medicine, Ankara, Turkey.
Insights
Irisin and asprosin levels are altered in prediabetes. Lifestyle changes improved these markers, suggesting their potential as diagnostic tools for prediabetes.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Biomarkers
Background:
- Prediabetes is a significant risk factor for type 2 diabetes.
- Identifying reliable biomarkers for prediabetes is crucial for early intervention.
Purpose of the Study:
- To investigate the role of irisin and asprosin in the pathophysiology of prediabetes.
- To evaluate the diagnostic potential of irisin and asprosin in prediabetes.
Main Methods:
- A prospective observational study involving 100 participants (60 prediabetes, 40 healthy).
- Measurement of irisin and asprosin levels in study groups.
- A 3-month lifestyle intervention program for prediabetes patients with reevaluation.
Main Results:
- Lower irisin and higher asprosin levels were observed in prediabetes patients compared to healthy individuals.
- Lifestyle intervention led to decreased asprosin and increased irisin levels, alongside improvements in insulin and HOMA index.
- Asprosin and irisin demonstrated diagnostic performance comparable to established markers like insulin and HOMA index.
Conclusions:
- Irisin and asprosin are associated with the prediabetes pathway.
- These hormones show potential as valuable diagnostic biomarkers in clinical practice for prediabetes.
Purpose:
We aimed to examine whether irisin and asprosin have a role in the physiopathology of prediabetes.
Methods:
Hundred people were selected between the age of 18-65 years for the study population (60 prediabetes, 40 healthy). For the follow-up study, the patients with prediabetes were offered a 3-month program for lifestyle change and then reevaluated. Our research is a single-center, prospective observational study.
Results:
Among the healthy group and patients with prediabetes, irisin levels were lower and asprosin levels were higher (p < 0.001) in patients. In the follow-up part, the patients' insulin levels, HOMA index scores, and asprosin levels were decreased while irisin levels were elevated (p < 0.001). Sensitivity was 98.3% and specificity was 65% for asprosin of > 56.3 ng/mL, while they were 93.3% and 65% for irisin of ≤ 120.2 pg/mL, respectively. It was found that irisin had diagnostic performance similar to insulin and the HOMA index, while asprosin performed similarly to glucose, insulin, and the HOMA index.
Conclusion:
Both irisin and asprosin have been found to be related to the prediabetes pathway and it has been shown that these molecules may be useful in daily clinical practice with diagnostic performances similar to those of the HOMA index and insulin.
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