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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Recent advances in SN-38 drug delivery system.
Jincheng Yang1, Lirui Jia2, Zhonggui He2
1Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, PR China; R&D Department, Ningxia Kangya Pharmaceutical Co., Ltd, Yinchuan 750002, PR China.
International Journal of Pharmaceutics
|March 26, 2023
Summary
7-ethyl-10-hydroxycamptothecin (SN-38) is a potent anticancer drug, but its poor solubility hinders delivery. Nanodrug systems are explored to improve its efficacy and overcome resistance in cancer treatment.
Area of Science:
- Biochemistry
- Pharmacology
- Nanotechnology
Background:
- DNA topoisomerase I is crucial for DNA replication and transcription.
- Camptothecin derivatives (CPTs), like SN-38, inhibit topoisomerase I and show anticancer activity.
- SN-38 exhibits potent cytotoxicity but suffers from poor solubility and stability, limiting its therapeutic application.
Purpose of the Study:
- To review nanodrug delivery systems for SN-38.
- To explore strategies for improving SN-38's physical and chemical properties.
- To discuss challenges in SN-38 formulation development and clinical translation.
Main Methods:
- Review of basic nanodrug delivery systems (nanoparticles, liposomes, micelles) for SN-38.
- Examination of functionalized nanodrug systems (prodrugs, active targeting, drug resistance overcoming).
Main Results:
- Various nanodrug systems effectively load SN-38, improving its delivery.
- Functionalized systems offer enhanced targeting and resistance circumvention.
- Challenges remain in formulation and clinical translation.
Conclusions:
- Nanodrug delivery systems show promise for overcoming SN-38's limitations.
- Further research is needed for optimized formulation and successful clinical application.
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