Therapeutic potential of marine peptides in malignant melanoma

Area of Science:

• Marine biology
• Cancer research
• Pharmacology

Background:

• Malignant melanoma (MM) is an aggressive skin cancer with increasing global incidence and resistance to conventional therapies.
• Current MM treatments are often ineffective, costly, and associated with significant adverse effects.
• Natural products, particularly from marine sources, are being explored for their anti-melanoma potential.

Purpose of the Study:

• To review marine peptides as potential therapeutic agents for malignant melanoma.
• To detail the molecular mechanisms of action of these marine-derived anticancer peptides.
• To highlight the safety and efficacy of marine peptides in combating MM.

Main Methods:

• Literature review of scientific studies on marine peptides and their effects on malignant melanoma.
• Analysis of research detailing the cytotoxic and therapeutic mechanisms of marine anticancer peptides.
• Synthesis of information on the chemopreventive and adjuvant roles of natural products in melanoma treatment.

Main Results:

• Marine peptides exhibit potent anticancer activities against melanoma cells.
• These peptides act through diverse mechanisms, including induction of apoptosis, inhibition of angiogenesis and metastasis, and disruption of cell viability.
• Marine peptides demonstrate a favorable safety profile, with reduced toxicity to healthy cells compared to traditional treatments.

Conclusions:

• Marine peptides represent a promising and safe therapeutic strategy for malignant melanoma.
• Their unique molecular mechanisms offer novel treatment avenues for this challenging cancer.
• Further research into marine peptides could lead to the development of effective drugs for melanoma treatment.