Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new hypothesis on tear film stability.

S Liotet1, O P Van Bijsterveld, O Kogbe

  • 1Hôpital des Quinze-Vingts, Paris, France.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|January 1, 1987
PubMed
Summary

The tear film

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiological changes in cutaneous lymphomas: an analysis of 8593 patients from the French Cutaneous Lymphoma Registry.

The British journal of dermatology·2020
Same author

Boosting the sterile insect technique with pyriproxyfen increases tsetse flies Glossina palpalis gambiensis sterilization in controlled conditions.

Scientific reports·2020
Same author

Atypical severe diffuse lamellar keratitis presenting as concentric rings after femtosecond laser-assisted small-incision lenticule extraction (SMILE).

Journal francais d'ophtalmologie·2020
Same author

Sterile keratitis following standard corneal collagen crosslinking: A case series and literature review.

Journal francais d'ophtalmologie·2019
Same author

[In vivo confocal microscopy and optical coherence tomography in stromal corneal dystrophies].

Journal francais d'ophtalmologie·2019
Same author

[Imaging of Reis-Bückler corneal dystrophy].

Journal francais d'ophtalmologie·2018

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biochemistry

Background:

  • The traditional view attributes tear film stability to mucus secreted by goblet cells.
  • This classical hypothesis faces several challenges and inconsistencies.
  • Emerging evidence suggests an alternative mechanism for tear film lubrication.

Purpose of the Study:

  • To investigate the primary agent responsible for tear film stability.
  • To re-evaluate the role of goblet cells and mucus in ocular surface health.
  • To propose a new therapeutic strategy for dry eye conditions.

Main Methods:

  • Electron microscopy analysis of ocular surface epithelial cells.
  • Examination of cellular structures like vesicles and glycocalyx.
  • Correlation of clinical observations with cellular morphology.

Main Results:

  • Electron microscopy revealed vesicles in the superficial epithelial layer and glycocalyx threads on microvilli.
  • These findings challenge the role of mucus as the primary surfacing agent.
  • The study suggests glycocalyx plays a crucial role in tear film stability.

Conclusions:

  • The tear film's stability is primarily maintained by the epithelial glycocalyx, not mucus.
  • Goblet cell loss in sicca syndrome is a consequence, not a cause, of dryness.
  • Therapeutic strategies should focus on epithelial cell regeneration for tear film stability.

Related Experiment Videos