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Updated: Aug 5, 2025

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
Baricitinib for the treatment of refractory vascular Behçet's disease
Zhimian Wang1, Xiaoou Wang1, Weiwei Liu2
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID); Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Objective:
The pilot study aims to evaluate the effectiveness and safety of baricitinib in Behcet's Disease (BD) patients with refractory vascular involvement.
Methods:
We consecutively enrolled vascular/cardiac BD patients who received baricitinib (2 mg/day) along with glucocorticoids (GCs) and immunosuppressants in our center. Efficacy assessment mainly depends on the proportion of clinical remission and side effects were recorded.
Results:
17 patients (12 males) were included with a mean follow-up of 10.7 ± 5.3 months. At 3 months of follow-up, 76.5% of patients achieved a complete response and the proportion increased to 88.2% at the last visit. During follow-up, ESR (p < 0.01) and hsCRP (p < 0.0001) decreased significantly, as well as Behçet's Disease Current Activity Form score (p < 0.01). In addition, baricitinib showed a GCs-sparing effect. No serious adverse events were noted.
Conclusions:
Our study suggests that baricitinib is well-tolerated and effective in treating refractory vascular/cardiac BD patients.
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