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Updated: Aug 5, 2025

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Immune tolerance breakdown in inborn errors of immunity: Paving the way to novel therapeutic approaches
Giuliana Giardino1, Roberta Romano1, Vassilios Lougaris2
1Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Abstract:
Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI.
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