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Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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Targeting epigenetic aberrations of sarcoma in CRISPR era
Miwa Tanaka1,2, Takuro Nakamura2
1Project for Cancer Epigenomics, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Genes, Chromosomes & Cancer
|March 26, 2023
Summary
Epigenetic aberrations are crucial for sarcoma development and progression. This review covers epigenetic changes, mouse models, and epigenome editing technologies for sarcoma research and therapy.
Area of Science:
- Oncology
- Genetics
- Epigenetics
Background:
- Sarcomas are rare cancers with diverse characteristics.
- Genetic alterations are key drivers of sarcomagenesis.
- Epigenetic aberrations cooperate with genetic mutations in sarcoma growth.
Purpose of the Study:
- To review epigenetic aberrations in sarcomas.
- To discuss representative mouse models for studying sarcoma.
- To explore epigenome editing technologies for sarcoma research and therapy.
Main Methods:
- Review of scientific literature on sarcoma epigenetics.
- Analysis of genetic and epigenetic interactions in sarcoma development.
- Examination of CRISPR/dCas9-based epigenome editing systems.
Main Results:
- Genetic alterations and epigenetic aberrations are integral to sarcomagenesis.
- Mouse models have significantly advanced understanding of sarcoma biology and tumor microenvironment.
- Epigenome editing technologies offer new avenues for research and therapeutic strategies.
Conclusions:
- Epigenetic aberrations are critical in sarcoma development.
- Advances in mouse models and epigenome editing enhance sarcoma research.
- Epigenetic therapies hold promise for sarcoma treatment.
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