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Blood prestin levels in COVID-19 patients
Mahfuz Turan1, Hamit Hakan Alp2, Hanifi Yildiz3
1Department of Otorhinolaryngology, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
Journal of the Chinese Medical Association : JCMA
|March 27, 2023
Summary
Serum prestin levels are elevated in COVID-19 patients compared to healthy individuals. This finding suggests prestin may indicate systemic dysfunction and could serve as a biomarker for coronavirus disease 2019 (COVID-19) infection severity.
Area of Science:
- Biochemistry
- Virology
- Otolaryngology
Background:
- Viral infections can impact various tissues, including the inner ear.
- Coronavirus disease 2019 (COVID-19) is a global health concern with potential multi-organ effects.
- Prestin, a motor protein in the inner ear and heart, is a potential biomarker for ototoxicity.
Purpose of the Study:
- To compare serum prestin levels in COVID-19 patients versus healthy volunteers.
- To investigate the correlation between prestin levels and markers of infection severity.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum prestin levels.
- Blood samples from 45 COVID-19 patients and 40 healthy controls were analyzed.
- Biochemical markers including LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer were quantified.
Main Results:
- COVID-19 patients exhibited significantly higher serum prestin levels than healthy controls (p < 0.001).
- A strong positive correlation was observed between prestin and C-reactive protein (CRP) (r = 0.654, p = 0.001).
- Significant positive correlations were also found between prestin and D-dimer (r = 0.659, p = 0.001).
Conclusions:
- Elevated serum prestin levels in COVID-19 patients suggest potential involvement of prestin-expressing tissues.
- The positive correlation with CRP and D-dimer indicates a link between prestin and systemic inflammation/coagulopathy in COVID-19.
- Prestin may serve as a potential biomarker for assessing COVID-19 severity and systemic effects.
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