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Updated: Aug 5, 2025
Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
Published on: September 20, 2018
Infantile perianal pyramidal protrusion: A retrospective review of 27 patients
Ramneek K Dhami1, Nasro A Isaq2, Megha M Tollefson2,3
1University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Insights
Infantile perianal pyramidal protrusion (IPPP) is a rare condition primarily affecting infant girls. Increased awareness can prevent unnecessary evaluations and overtreatment for this benign condition.
Area of Science:
- Dermatology
- Pediatrics
Background:
- Infantile perianal pyramidal protrusion (IPPP) is a rare, benign pediatric skin condition.
- Often misdiagnosed as other lesions, leading to unwarranted investigations and treatments.
- Clinician unfamiliarity contributes to diagnostic challenges.
Purpose of the Study:
- To characterize demographic data and clinical features of IPPP.
- To analyze diagnostic workup and management strategies for IPPP.
- To provide insights from a large patient cohort at an academic medical center.
Main Methods:
- Retrospective review of patients diagnosed with IPPP.
- Data collection included demographics, examination findings, diagnostic procedures, and treatments.
- Analysis of cases from a single academic medical center.
Main Results:
- Twenty-seven patients identified (24 girls, 3 boys), ages 1 day to 4 years.
- Symptoms reported in 63% of cases; constipation was a common associated symptom.
- Four patients received topical treatment; no skin biopsies were performed.
Conclusions:
- IPPP is frequently observed in healthy, prepubertal girls.
- Constipation is a notable accompanying symptom.
- Enhanced clinical awareness can prevent overtreatment and reduce unnecessary diagnostic evaluations.
Background:
Infantile perianal pyramidal protrusion (IPPP) is a rare benign skin condition that is typically seen in infant girls. This condition is often mistaken for other skin lesions such as acrochordons, condyloma acuminatum, and sequelae of sexual abuse. Many clinicians are unfamiliar with IPPP which can lead to aggressive workup and treatment. The purpose of this study was to elucidate demographic data, clinical features, diagnostic workup, and management of IPPP in a large cohort of patients seen at an academic medical center.
Methods:
A retrospective review of patients diagnosed with IPPP at Mayo Clinic, Rochester, MN was conducted. Demographic data, examination findings, diagnostic workup, and treatments were noted.
Results:
Twenty-seven patients with IPPP, 24 of which were girls and 3 were boys from the ages of 1 day to 4 years (mean 10.8 months, median 8.6 months) were identified. Symptoms were reported in 63% (17/27) of patients. Four patients received treatment with topical corticosteroid or local anesthetic. No patient underwent skin biopsy.
Conclusion:
IPPP is commonly observed in healthy prepubertal girls. Constipation is a common symptom. Awareness of this entity may prevent overtreatment and unnecessary evaluation.
