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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease III: Medical Management01:21

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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Rheumatoid factor is associated with severe COVID-19.

Hyemin Jeong1, Ae Rin Baek2, Sung Woo Park2

  • 1Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, South Korea.

International Journal of Rheumatic Diseases
|March 27, 2023
PubMed
Summary

Rheumatoid factor (RF) and antinuclear antibodies (ANA) are common in COVID-19 patients. RF is a significant risk factor for critical COVID-19, indicating immune dysfunction contributes to disease severity.

Keywords:
COVID-19antinuclear antibodyrheumatoid factor

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Autoimmunity

Background:

  • COVID-19 has been linked to the development of autoimmune conditions.
  • Understanding the role of autoantibodies in COVID-19 pathogenesis is crucial.

Purpose of the Study:

  • To investigate the prevalence of autoantibodies in hospitalized COVID-19 patients.
  • To determine the clinical significance of these autoantibodies, particularly their association with disease severity and mortality.

Main Methods:

  • Retrospective analysis of 245 hospitalized COVID-19 patients.
  • Testing for antinuclear antibody (ANA), rheumatoid factor (RF), anti-citrullinated peptide antibody (ACPA), and anti-cytoplasmic neutrophil antibody (ANCA).
  • Analysis of risk factors for death and critical COVID-19 (defined by mechanical ventilation or ECMO).

Main Results:

  • 36.7% of patients had ANA, and 20.8% had RF.
  • RF-positive patients showed significantly higher rates of mechanical ventilation and death.
  • RF, quick COVID severity index (qCSI), and lactate dehydrogenase (LDH) were independently associated with critical COVID-19.
  • A combination of RF, qCSI, and LDH demonstrated strong prognostic value for critical COVID-19.

Conclusions:

  • ANA and RF are frequently observed in COVID-19.
  • Rheumatoid factor is identified as a potential risk factor for critical COVID-19 outcomes.
  • These findings suggest that immune dysregulation plays a role in COVID-19 complications.