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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Aug 5, 2025

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models

Published on: September 18, 2018

The Mouse Models of Human Cancer database (MMHCdb).

Dale A Begley¹, Debra M Krupke¹, John P Sundberg¹

¹The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Disease Models & Mechanisms

|March 27, 2023

Summary

This summary is machine-generated.

The Mouse Models of Human Cancer database (MMHCdb) standardizes data for mouse cancer models, improving research accuracy. This resource aids in understanding genetic impacts on cancer and evaluating mouse strains for human cancer studies.

Keywords:

Cancer Database Genetic background Mouse models Nomenclature

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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

Area of Science:

Oncology
Genomics
Bioinformatics

Background:

Laboratory mice are crucial for studying human cancer genetics and genomics.
Existing mouse cancer models lack standardized nomenclature and annotation, hindering data aggregation.
Thousands of mouse models exist, but knowledge compilation is challenging due to data inconsistencies.

Purpose of the Study:

To introduce the Mouse Models of Human Cancer database (MMHCdb) as a standardized resource.
To address the lack of compliance with nomenclature and annotation standards in published literature.
To facilitate comprehensive and accurate searches for mouse models of human cancer.

Main Methods:

Expert curation of diverse mouse models including inbred strains, genetically engineered models, patient-derived xenografts, and diversity panels.
Enforcement of FAIR-compliant nomenclature and annotation standards.
Development of a comprehensive knowledgebase for mouse models of human cancer.

Main Results:

The MMHCdb provides a FAIR-compliant knowledgebase for mouse cancer models.
The database enforces standardized nomenclature and annotation for genes, alleles, strains, and cancer types.
It supports accurate and complete searches for mouse models and associated data.

Conclusions:

The MMHCdb enhances the analysis of genetic background effects on tumor incidence and presentation.
It aids in assessing the suitability of different mouse strains for modeling human cancer biology and treatment response.
Standardization through MMHCdb improves the utility of mouse models in cancer research.