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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Causal relationship between thyroid dysfunction and hallux valgus: A two-sample Mendelian randomization study.

Binglang Xiong1, Zixing Bai1, Xuhan Cao1

  • 1Second Department of Orthopedics, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.

Frontiers in Endocrinology
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Hypothyroidism, a thyroid dysfunction, causally increases the risk of hallux valgus (HV). This genetic link suggests early prevention strategies for hallux valgus in patients with hypothyroidism.

Keywords:
Mendelian randomization analysiscausalityhallux valgushypothyroidismthyroid

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Area of Science:

  • Medical Genetics
  • Endocrinology
  • Orthopedics

Background:

  • Observational studies suggest a link between thyroid dysfunction and hallux valgus (HV).
  • The causal relationship between thyroid dysfunction and HV remains unclear.
  • Thyroid hormones play a crucial role in various bodily functions, potentially influencing musculoskeletal health.

Purpose of the Study:

  • To investigate the potential causal effect of thyroid dysfunction on hallux valgus (HV) using a two-sample Mendelian randomization (MR) approach.
  • To determine if specific thyroid conditions, such as hypothyroidism and hyperthyroidism, are genetically linked to HV.
  • To assess the genetic association of thyroid hormone levels (free thyroxine and TSH) with HV.

Main Methods:

  • A two-sample Mendelian randomization (MR) study utilizing publicly available genome-wide association study (GWAS) data.
  • Exposures included hypothyroidism, hyperthyroidism, free thyroxine (FT4), and thyrotropin (TSH), with single nucleotide polymorphisms (SNPs) sourced from large-scale GWAS.
  • Hallux valgus (HV) served as the outcome, with associated SNPs obtained from a comprehensive GWAS; inverse variance weighted (IVW) method was primary, supported by sensitivity analyses.

Main Results:

  • A significant causal effect of hypothyroidism on hallux valgus (HV) was identified, indicating hypothyroidism increases HV incidence (OR = 2.838, p = 0.028).
  • No significant causal relationships were found between hyperthyroidism, FT4, or TSH and hallux valgus (p > 0.05).
  • Sensitivity analyses confirmed the robustness and reliability of the findings, with no evidence of horizontal pleiotropy.

Conclusions:

  • The study provides strong genetic evidence supporting a causal link between hypothyroidism and an increased risk of developing hallux valgus (HV).
  • These findings highlight the importance of monitoring for HV in individuals with hypothyroidism.
  • The results suggest potential for early prediction, prevention, and intervention strategies for hallux valgus in hypothyroid patients.