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Related Experiment Video

Updated: Aug 5, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Alterations in white matter integrity and network topological properties are associated with a decrease in global

Shizhen Yan¹, Yuping Zhang², Xiaojuan Yin¹

¹Faculty of Psychology, Tianjin Normal University, Tianjin, China.

Frontiers in Aging Neuroscience

|March 27, 2023

Summary

Aging reduces global motion perception (GMP) due to decreased white matter (WM) integrity and network efficiency. This study links reduced fractional anisotropy in specific WM tracts to impaired GMP in older adults.

Keywords:

TBSS aging global motion perception structural network white matter

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Area of Science:

Neuroscience
Aging Research
Visual Perception

Background:

Previous research focused on cortical aging's impact on global motion sensitivity.
The white matter (WM) structural basis for age-related decline in global motion perception (GMP) remains unexplored.

Purpose of the Study:

To investigate the relationship between WM integrity, network connectivity, and GMP in older adults.
To identify specific WM tracts and network properties associated with age-related GMP decline.

Main Methods:

Employed diffusion tensor imaging (DTI) and random dot kinematogram (RDK) tasks.
Recruited 106 younger and 94 older adults for analysis.
Utilized tract-based spatial statistics (TBSS) and graph theoretical analysis.

Main Results:

Reduced GMP in older adults correlated with decreased fractional anisotropy (FA) in key WM tracts, including the inferior frontal-occipital fasciculus and superior longitudinal fasciculus.
Lower global efficiency and increased characteristic path length in the WM structural network were associated with diminished global motion sensitivity.
Findings support the disconnection hypothesis of cognitive aging.

Conclusions:

Age-related GMP decline is linked to compromised WM integrity in specific fiber tracts.
Reduced efficiency in information integration and inter-regional communication within the WM network contributes to impaired GMP.
White matter alterations play a critical role in age-associated visual processing deficits.